Mayo Research Provides Information on High-Risk Youth Demographics for Severe COVID-19
Newswise – ROCHESTER, Minnesota Using data from 9,859 COVID-19 infections, researchers at the Mayo Clinic have new insight into risk factors for younger populations, some of which differ significantly from their older counterparts. People under 45 have a more than three times higher risk of serious infection if they have cancer or heart disease, or blood, neurological or endocrine disorders, according to research. These associations were weaker in the older groups. The study was published in Mayo Clinic Proceedings.
The research team studied people living in an area of 27 counties in southeastern Minnesota and midwestern Wisconsin surrounding the Mayo Clinic in Rochester diagnosed with COVID-19 between March and September 2020. The study has used the Rochester Epidemiology Project, a linkage of 1.7 million medical records from multiple health care systems that provides a comprehensive picture of risks for an entire geographic region.
“Medical care is really fragmented in our country, so a person diagnosed with COVID-19 at a health care provider could end up in an entirely different hospital for their severe case. If these records are not linked together, there really is no good way for us to understand that it is even the same patient, ”says Jennifer St. Sauver, Ph.D., epidemiologist at the Mayo Clinic and the study’s first author. “In contrast, the Rochester Epidemiology Project has allowed us to follow patients from the time they were diagnosed until their use of health care after that diagnosis, even though they were treated in different locations. records to better understand all the chronic diseases this population had even before being diagnosed with COVID-19 and how these diseases could have contributed to more serious infections. “
Among study participants, cancer was the greatest difference in risk when comparing people under 45 and those under 45. For people under 45, cancer was a significant risk factor. It was not a significant factor for the older age group.
Researchers also found that people with developmental disabilities, personality disorders, schizophrenia and other psychoses had the highest adjusted risk of severe COVID-19 among all chronic diseases.
Like many other studies on risk factors for COVID-19, researchers found that certain races and ethnicities were at greater risk than others. Although only 4.1% of the study population, Asian Americans had the highest risk of severe COVID-19, followed by black Americans, who accounted for 11.5% of severe cases. Hispanic ethnicity was also associated with a higher risk of serious infection.
The team studied positive PCR (polymerase chain reaction) tests for COVID-19 between March 1 and September 30, 2020.
The COVID in our community-based research study is being conducted by the Mayo Clinic, Olmsted County Public Health Department, Olmsted Medical Center, and Zumbro Valley Health Center. The researchers say the project would not have been possible without the Rochester Epidemiology Project.
“The Rochester Epidemiology Project allows us to study diseases, such as COVID-19, in a defined population, which offers the opportunity to translate our findings to all people with COVID-19, not just those with most serious disease requiring medical attention, ”says lead author Céline Vachon, Ph.D., chair of the epidemiology division of the Mayo Clinic. “This type of infrastructure will allow us to track patients with COVID-19 in the 27-county region over time to better understand any future links to the disease. “
The project was also supported by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery and the Mayo Clinic COVID-19 Research Fund.
The co-authors are Guilherme Lopes, Ph.D., Mayo Clinic; Walter Rocca, MD, Mayo Clinic; Kavita Prasad, MD, Zumbro Valley Health Center; Michelle Majerus, Olmsted Medical Center; Andrew Limper, MD, Mayo Clinic; Debra J. Jacobson, Mayo Clinic; Chun Fan, Mayo Clinic; Robert Jacobson, MD, Mayo Clinic; Lila Rutten, Ph.D., Mayo Clinic; and Aaron Norman, Mayo Clinic.
About the Rochester Epidemiology Project
The Rochester Epidemiology Project is a collaboration of clinics, hospitals, and other medical and dental facilities in southern Minnesota and western Wisconsin. Founded by the Mayo Clinic and the Olmsted Medical Center in 1966 in Olmsted County, Minnesota, the collaboration now spans 27 counties and includes the Olmsted County Public Health Departments as the first member of Health public. This collaboration and sharing of medical information makes this region of Minnesota and Wisconsin one of the few places where true population-based research can be done. For more information on the Rochester Epidemiology Project, check out its new historical timeline. Also visit the Rochester Epidemiology Project website.
About the Mayo Clinic
Mayo Clinic is a non-profit organization committed to innovation in clinical practice, education, and research, and providing compassion, expertise, and answers to all in need of healing. Visit the Mayo Clinic News Network for more information on the Mayo Clinic. For more information on COVID-19, including the Mayo Clinic Coronavirus Map Tracker, which has 14-day forecasts of COVID-19 trends, visit the COVID-19 Resource Center at the Mayo Clinic.